Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors.
Todd M Gibson et al. Nat Med 2024 3
(Posted: Mar 12, 2024 0PM)
Health-Related quality of life and DNA Methylation-Based aging biomarkers among survivors of childhood cancer.
Noel-Marie Plonski et al. J Natl Cancer Inst 2024 3
(Posted: Mar 07, 2024 8AM)
Clinical trio genome sequencing facilitates the interpretation of variants in cancer predisposition genes in paediatric tumour patients
C. Shroeder et al, EJHG, July 28, 2023
(Posted: Jul 28, 2023 8AM)
Precision Medicine Is Changing the Roles of Healthcare Professionals, Scientists, and Research Staff: Learnings from a Childhood Cancer Precision Medicine Trial
R Daly et al, JPM, June 23, 2023
(Posted: Jun 24, 2023 10AM)
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
Y Liu et al, Nat Comm, April 5, 2023
(Posted: Apr 05, 2023 6AM)
Diagnostic classification of childhood cancer using multiscale transcriptomics.
Federico Comitani et al. Nature medicine 2023 3
(Posted: Mar 20, 2023 7AM)
Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm.
Jette J Bakhuizen et al. JAMA network open 2023 2 (2) e2254157
(Posted: Feb 04, 2023 7AM)
Heterozygous BRCA1/2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents with Cancer.
Kratz Christian P et al. Journal of the National Cancer Institute 2022 8
(Posted: Aug 19, 2022 11AM)
Predicting chronic morbidity in childhood cancer survivors.
Vrooman Lynda M et al. Nature medicine 2022 8
(Posted: Aug 09, 2022 7AM)
Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer.
Sapkota Yadav et al. Nature medicine 2022 7
(Posted: Jul 26, 2022 7AM)
Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer
Q Dong et al, Genome Medicine, March 22, 2022
(Posted: Mar 23, 2022 8AM)
Performance of the McGill Interactive Pediatric OncoGenetic Guidelines for Identifying Cancer Predisposition Syndromes.
Goudie Catherine et al. JAMA oncology 2021 10
(Posted: Oct 08, 2021 5AM)
Comprehensive germline-genomic and clinical profiling in 160 unselected children and adolescents with cancer
R Wagener et al, EJHG< April 12, 2021
(Posted: Apr 12, 2021 8AM)
Entering the era of precision medicine in pediatric oncology
D Hadjdadj et al, Nature Medicine, October 19, 2020
(Posted: Oct 19, 2020 0PM)
Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
M Wong et al, Nature Medicine, October 5, 2020
(Posted: Oct 05, 2020 2PM)
Precision medicine has a blind spot: children with cancer
G Nichols, StatNews, December 30, 2019
(Posted: Dec 31, 2019 9AM)
Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer
OM Vaske et al, JAMA Network Open, October 25, 2019
(Posted: Oct 27, 2019 11AM)
Easing the Burden of Children and Families Dealing with Cancer
JE Bloyd, CDC Cancer Blog, October 2019
(Posted: Oct 08, 2019 8AM)
The Promise and the Reality of Genomics to Guide Precision Medicine in Pediatric Oncology: The Decade Ahead.
Evans William E et al. Clinical pharmacology and therapeutics 2019 Sep
(Posted: Oct 02, 2019 8AM)
The Childhood Cancer Data Initiative: Transforming the Pediatric Cancer Landscape through Sharing Data
DR Lowy, NCI, August 15, 2019
(Posted: Aug 19, 2019 8AM)
Genetics-related service and information needs of childhood cancer survivors and parents: a mixed-methods study
J Vetsch et al, Eur J Hum Genetics, July 30, 2019
(Posted: Jul 31, 2019 10AM)
Childhood Cancer Data Initiative (CCDI) Symposium
NCI, July 29-31, 2019
(Posted: Jul 30, 2019 8AM)
Association of Germline BRCA2 Mutations With the Risk of Pediatric or Adolescent Non-Hodgkin Lymphoma.
Wang Zhaoming et al. JAMA oncology 2019 Jul
(Posted: Jul 28, 2019 4PM)
The Childhood Cancer Data Initiative: Why Data Sharing Is Essential to Progress
D Lowy, NCI Director Blog, June 12, 2019
(Posted: Jun 12, 2019 10AM)
2019 ASCO: Nearly One-Quarter of Participants in the Pediatric MATCH Trial Have an Actionable Molecular Alteration
by Jo Cavallo, the ASCO Post, May 15, 2019
(Posted: May 16, 2019 8AM)
Molecular Profiling of Hard-to-Treat Childhood and Adolescent Cancers
F Khater et al, JAMA Network Open, April 25, 2019
(Posted: Apr 28, 2019 7AM)
Genetic Profiling May Inform Breast Cancer Risk in Young Childhood Cancer Survivors
AACR News, October 25, 2018
(Posted: Oct 26, 2018 11AM)
Investigation of clinically relevant germline variants detected by next-generation sequencing in patients with childhood cancer: a review of the literature.
Sylvester Dianne E et al. Journal of medical genetics 2018 Oct
(Posted: Oct 10, 2018 7AM)
The next frontier in the battle against childhood cancer: Genetics and genomics
N Blanton, Baylor Medicine, Blog, October 9, 2018
(Posted: Oct 09, 2018 1PM)
Finding Pediatric Cancer Genomic Data through PGDI
NCI, September 2018
(Posted: Sep 09, 2018 10AM)
The genomic landscape of pediatric cancers
MassGenomics, Blog Mar 2018
(Posted: Mar 13, 2018 9AM)
Working Toward Greater Precision in Childhood Cancers
NIH Director Blog, Mar 6, 2018
(Posted: Mar 11, 2018 0PM)
Landscapes of childhood tumours
Nature News and Views, Feb 2018
(Posted: Mar 03, 2018 9AM)
Crizotinib Shows Promise for Childhood Cancers
(Posted: Sep 06, 2017 8AM)
NCI-COG Pediatric MATCH trial to test targeted drugs in childhood cancers
NCI, July 2017
(Posted: Jul 27, 2017 7PM)
Recommendations for Childhood Cancer Screening and Surveillance in DNA Repair Disorders.
Walsh Michael F et al. Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Jun 23(11) e23-e31
(Posted: Jun 07, 2017 9AM)
Childhood Cancer Genomics (PDQ®) Health Professional Version
(Posted: Jun 07, 2017 8AM)
Pediatric cancers and precision medicine: The feasibility question
Vector, Boston Children Hospital, February, 2016
(Posted: Feb 08, 2016 9AM)
Genetic sequencing can help guide treatment in children with solid tumors,
Dana-Faber Cancer Institute, January 28, 2016
(Posted: Feb 03, 2016 3PM)
A Quality Improvement Collaborative to Improve Pediatric Primary Care Genetic Services.
Rinke Michael L et al. Pediatrics 2016 Jan
(Posted: Feb 03, 2016 3PM)
Recognition of genetic predisposition in pediatric cancer patients: An easy-to-use selection tool.
Jongmans Marjolijn C J et al. European journal of medical genetics 2016 Jan
(Posted: Feb 03, 2016 3PM)
Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors
D Williams-Parson et al, JAMA Oncology, January 28, 2016
(Posted: Jan 29, 2016 11AM)
Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors- The Individualized Cancer Therapy (iCat) Study
MH Harris et al, JAMA Oncology, January 28, 2016
(Posted: Jan 29, 2016 7AM)
Precision Therapy for Pediatric Cancers
J Khan et al, JAMA Oncology, January 28, 2016
(Posted: Jan 29, 2016 7AM)
Defining Why Cancer Develops in Children
JM Maris, NEJM November 18, 2015
(Posted: Nov 18, 2015 8PM)
Germline Mutations in Predisposition Genes in Pediatric Cancer
J Zhang et al. NEJM, November 18, 2015
(Posted: Nov 18, 2015 7PM)
For Some Children with Cancer, Genomic Information May Help Guide Treatment Decisions
NCI, September 18, 2015
(Posted: Sep 20, 2015 7AM)
Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth
RJ Mody et al. JAMA, September 1, 2015
(Posted: Sep 01, 2015 4PM)
Improving Patient Outcomes With Cancer Genomics
Unique Opportunities and Challenges in Pediatric Oncology
RW Schnepp et al. JAMA< September 1, 2015
(Posted: Sep 01, 2015 4PM)
How Can Precision Medicine Help Children With Cancer?
S Ravoori, AACR Blog Post, July 29, 2015
(Posted: Aug 03, 2015 1PM)
Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk.
Ghantous Akram et al. Mutagenesis 2015 Feb 26.
(Posted: Mar 08, 2015 6PM)
CDC Information: Cancer Prevention Starts in Childhood
(Posted: Feb 25, 2015 0PM)
Obtaining informed consent for clinical tumor and germline exome sequencing of newly diagnosed childhood cancer patients.
Scollon Sarah et al. Genome medicine 2014 (9) 69
(Posted: Feb 12, 2015 8AM)
Precision Medicine Trials for Cancer: A New Era
(Posted: Jan 11, 2014 11AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Apr 29, 2024
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